Article
Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish.
Developmental biology - 15 Aug 2004
Seiler Christoph, Ben-David Orit, Sidi Samuel, Hendrich Oliver, Rusch Alfons, Burnside Beth, Avraham Karen B, Nicolson Teresa
Abstract excerpt
Unconventional myosins have been associated with hearing loss in humans, mice, and zebrafish. Mutations in myosin VI cause both recessive and dominant forms of nonsyndromic deafness in humans and deafness in Snell's waltzer mice associated with abnormal fusion of hair cell stereocilia. Although myosin VI has been implicated in diverse cellular processes such as vesicle trafficking and epithelial morphogenesis,...
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