Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

Developmental biology - 15 Apr 2005

Huang Liang, Ohsako Shunji, Tanda Soichi

Abstract excerpt

The lesswright (lwr) gene encodes an enzyme that conjugates a small ubiquitin-related modifier (SUMO). Since the conjugation of SUMO occurs in many different proteins, a variety of cellular processes probably require lwr function. Here, we demonstrate that lwr function regulates the production of blood cells (hemocytes) in Drosophila larvae. lwr mutant larvae develop many melanotic tumors in the hemolymph at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoiesis
Share to Hemocytes
Share to Larva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoproteins

Share to Transgenes

Share to Ubiquitin

Share to Ubiquitin-Conjugating Enzyme UBC9

Share to Ubiquitin-Conjugating Enzymes

Source

Identifiers

PMID: 15882582
DOI: 10.1016/j.ydbio.2005.02.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.PMID 15882582Read ↗

Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.Semantic proximity Read ↗

dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila.Semantic proximity Read ↗

Single-cell transcriptome maps of myeloid blood cell lineages in DrosophilaSemantic proximity Read ↗

Drosophila Rel proteins are central regulators of a robust, multi-organ immune network.Semantic proximity Read ↗

Cloning of the neurodegeneration gene drop-dead and characterization of additional phenotypes of its mutation.Semantic proximity Read ↗

Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland.Semantic proximity Read ↗

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense.Semantic proximity Read ↗

Sex differences in the regulation and function of cellular immunity in <i>Drosophila</i>Semantic proximity Read ↗

Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap.Semantic proximity Read ↗

Jumu is required for the activation of JAK/STAT in Drosophila lymph gland development and epidermal wounds.Semantic proximity Read ↗

Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.Semantic proximity Read ↗

<i>Drosophila</i> Hox genes induce melanised pseudo-tumours when misexpressed in hemocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.