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Article

Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival.

Nature immunology - 1 Jun 2005

Arellano-Reynoso Beatriz, Lapaque Nicolas, Salcedo Susana, Briones Gabriel, Ciocchini Andrés Eduardo, Ugalde Rodolfo, Moreno Edgardo, Moriyón Ignacio, Gorvel Jean-Pierre

Abstract excerpt

Pathogenic brucella bacteria have developed strategies to persist for prolonged periods of time in host cells, avoiding innate immune responses. Here we show that the cyclic beta-1,2-glucans (CbetaG) synthesized by brucella is important for circumventing host cell defenses. CbetaG acted in lipid rafts found on host cell membranes. CbetaG-deficient mutants failed to prevent phagosome-lysosome fusion and could not...

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PMID: 15880113
DOI: 10.1038/ni1202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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