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Article

Association between sequence variations in genes encoding human zona pellucida glycoproteins and fertilization failure in IVF.

Human reproduction (Oxford, England) - 1 Jun 2005

Männikkö M, Törmälä R-M, Tuuri T, Haltia A, Martikainen H, Ala-Kokko L, Tapanainen J S, Lakkakorpi J T

Abstract excerpt

BACKGROUND: The zona pellucida (ZP) has multiple roles in reproductive processes, including oocyte maturation, fertilization and implantation. We used, for the first time, a genetic approach to study whether human ZP genes possess structural alterations in women with unsuccessful IVF trials. In theory, this may result in gradual reduction of sperm-zona interaction and eventually in total fertilization failure...

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Share to Egg Proteins
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fertilization in Vitro

Share to Infertility, Female

Share to Receptors, Cell Surface

Share to Sequence Analysis

Share to Sperm Injections, Intracytoplasmic

Share to Treatment Failure

Source

Identifiers

PMID: 15860499
DOI: 10.1093/humrep/deh837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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