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Biochemical Characterization of Rous Sarcoma Virus MA Protein Interaction with Membranes

27 Apr 2005

Abstract excerpt

The MA domain of retroviral Gag proteins mediates association with the host cell membrane during assembly. The biochemical nature of this interaction is not well understood. We have used an in vitro flotation assay to directly measure Rous sarcoma virus (RSV) MA-membrane interaction in the absence of host cell factors. The association of purified MA and MA-containing proteins with liposomes of defined composition...

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PMID: 15858007
DOI: 10.1128/jvi.79.10.6227-6238.2005

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