Article
Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids.
The Journal of biological chemistry - 13 Feb 2009
Dancho Brooke, McKenzie Margie O, Connor John H, Lyles Douglas S
Abstract excerpt
Viral matrix (M) proteins bind the nucleoprotein core (nucleocapsid) to host membranes during the process of virus assembly by budding. Previous studies using truncated M proteins had implicated the N-terminal 50 amino acids of the vesicular stomatitis virus M protein in binding both membranes and nucleocapsids and a sequence from amino acids 75-106 as an additional membrane binding region. Structure-based...
Topics
- Animals
- Cell Line
- Cell Membrane
- Cricetinae
- Mutation
- Nucleocapsid
- Protein Structure, Tertiary
- Vesiculovirus
- Viral Matrix Proteins
- Virus Replication