Article
Reversed diurnal variation in depression: associations with a differential antidepressant response, tryptophan: large neutral amino acid ratio and serotonin transporter polymorphisms.
Psychological medicine - 1 Apr 2005
Joyce Peter R, Porter Richard J, Mulder Roger T, Luty Suzanne E, McKenzie Janice M, Miller Allison L, Kennedy Martin A
Abstract excerpt
BACKGROUND: Although diurnal variation of mood is a widely recognized symptom of depression, the clinical, neurobiological and psychopharmacological significance of this symptom has not previously been reported. METHOD: A total of 195 depressed out-patients underwent a detailed clinical and neurobiological assessment, and were then randomized to treatment with either fluoxetine or nortriptyline. RESULTS: Of the...
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