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Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach

27 Apr 2005

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) displays striking heterogeneity at the clinical, genetic, and molecular levels. Clinical prognostic models can define a population at high risk for relapse following empiric chemotherapy, although such models do not account for underlying biologic differences among tumors. Commonly observed genetic abnormalities that likely contribute to pathogenesis include translocations of...

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PMID: 15855278
DOI: 10.1182/blood-2005-02-0687

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