Article
Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis.
The American journal of pathology - 1 Jan 2010
Seier Anne M, Renkl Andreas C, Schulz Guido, Uebele Tanja, Sindrilaru Anca, Iben Sebastian, Liaw Lucy, Kon Shigeyuki, Uede Toshimitsu, Weiss Johannes M
Abstract excerpt
Allergic contact dermatitis is a T cell-mediated immune response, which in its relapsing chronic form is of high socioeconomic impact. The phosphoglycoprotein osteopontin (OPN) has chemotactic and Th1 cytokine functions and in various models is essential for robust T cell-mediated immunity. Here...
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