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Article

Nonnucleoside reverse transcriptase inhibitor phenotypic hypersusceptibility can be demonstrated in different assays.

Journal of acquired immune deficiency syndromes (1999) - 1 May 2005

Shulman Nancy S, Delgado Jamael, Bosch Ronald J, Winters Mark A, Johnston Elizabeth, Shafer Robert W, Katzenstein David A, Merigan Thomas C

Abstract excerpt

BACKGROUND: HIV-1 isolates harboring multiple nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations are more susceptible ("hypersusceptible") to the nonnucleoside reverse transcriptase inhibitors (NNRTIs) than isolates lacking NRTI resistance mutations, but this has only been reported with a single-cycle replication phenotypic assay. In fact, there was a report that a commercial multicycle assay...

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Identifiers

PMID: 15851917
DOI: 10.1097/01.qai.0000159517.78100.7b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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