Modeling the effects of mutations on the denatured states of proteins.

doi:10.1002/pro.5560010202

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Article

Modeling the effects of mutations on the denatured states of proteins.

Protein science : a publication of the Protein Society - 1 Feb 1992

Shortle D, Chan H S, Dill K A

Abstract excerpt

We develop a model for the reversible denaturation of proteins and for the effects of single-site mutations on the denatured states. The model is based on short chains of sequences of H (hydrophobic) and P (other) monomers configured as self-avoiding walks on the two-dimensional square lattice. T...

Topics

Amino Acid Sequence
Chemical Phenomena
Chemistry, Physical
Computer Simulation
Models, Chemical
Mutation
Protein Conformation
Protein Denaturation
Protein Folding
Proteins
Solubility
Solvents

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