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Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle

16 Jan 2001

Abstract excerpt

Nuclear reprogramming requires the removal of epigenetic modifications imposed on the chromatin during cellular differentiation and division. The mammalian oocyte can reverse these alterations to a state of totipotency, allowing the production of viable cloned offspring from somatic cell nuclei. To determine whether nuclear reprogramming is complete in cloned animals, we assessed the telomerase activity and...

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PMID: 11158597
DOI: 10.1073/pnas.98.3.1077

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