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Telomerase-immortalized sheep fibroblasts can be reprogrammed by nuclear transfer to undergo early development.

Biology of reproduction - 1 Jul 2003

Cui Wei, Wylie Diana, Aslam Samena, Dinnyes Andres, King Tim, Wilmut Ian, Clark A John

Abstract excerpt

Telomere shortening and lack of telomerase activity have been implicated in cellular senescence in human fibroblasts. Expression of the human telomerase catalytic reverse transcriptase subunit (hTERT) in these cells reconstitutes telomerase activity and immortalizes the cells without tumor transformation. In this report, we show that sheep fibroblasts are similar to human cells. They do not have detectable...

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Identifiers

PMID: 12606403
DOI: 10.1095/biolreprod.102.013250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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