Article
Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach.
The pharmacogenomics journal - 1 Aug 2007
Rodd Z A, Bertsch B A, Strother W N, Le-Niculescu H, Balaraman Y, Hayden E, Jerome R E, Lumeng L, Nurnberger J I, Edenberg H J, McBride W J, Niculescu A B
Abstract excerpt
We describe a comprehensive translational approach for identifying candidate genes for alcoholism. The approach relies on the cross-matching of animal model brain gene expression data with human genetic linkage data, as well as human tissue data and biological roles data, an approach termed convergent functional genomics. An analysis of three animal model paradigms, based on inbred alcohol-preferring (iP) and...
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