Article
Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation.
Biochimica et biophysica acta - 15 May 2005
Koenderink Jan B, Zifarelli Giovanni, Qiu Li Yan, Schwarz Wolfgang, De Pont Jan Joep H H M, Bamberg Ernst, Friedrich Thomas
Abstract excerpt
The Na,K-ATPase is an ion-translocating transmembrane protein that actively maintains the electrochemical gradients for Na+ and K+ across the plasma membrane. The functional protein is a heterodimer comprising a catalytic alpha-subunit (four isoforms) and an ancillary beta-subunit (three isoforms). Mutations in the alpha2-subunit have recently been implicated in familial hemiplegic migraine type 2, but almost no...
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