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Article

Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection.

The American journal of gastroenterology - 1 May 2005

Yuen Man-Fung, Wong Danny Ka-Ho, Sum Simon Siu-Man, Yuan He-Jun, Yuen John Chi-Hang, Chan Annie On-On, Wong Benjamin Chun-Yu, Lai Ching-Lung

Abstract excerpt

OBJECTIVE: To determine the effect of 1-yr lamivudine treatment on serum covalently closed-circular DNA (cccDNA) level. PATIENTS AND METHOD: Serum total HBV DNA and cccDNA levels at baseline, week 24, and week 52 were measured in 82 lamivudine-treated patients, 17 of whom received 1-yr placebo and acted as controls. RESULTS: There was a significant reduction in the cccDNA levels from baseline (median 3.0 x 10(6)...

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Identifiers

PMID: 15842584
DOI: 10.1111/j.1572-0241.2005.41530.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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