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Article

Genetic and biochemical analysis of ribosomal proteins of minocycline-susceptible and -resistant Mycobacterium smegmatis.

Microbiology and immunology - 1 Jan 1992

Yamada T, Mizuguchi Y, Isono S, Isono K

Abstract excerpt

A minocycline (MINO)-resistant mutant was isolated from Mycobacterium smegmatis strain Rabinowitschi. Polypeptide synthesis in the cell-free system prepared from the mutant was resistant to minocycline (MINO) because of alterated 30S ribosomal subunits. Upon two-dimensional gel electrophoresis, two proteins of 30S subunit were found to be altered. MINO resistance phenotype was transferred by mating to the...

Topics

Bacterial Proteins
Electrophoresis, Gel, Two-Dimensional
Microbial Sensitivity Tests
Minocycline
Mutation
Mycobacterium
Recombination, Genetic
Ribosomal Proteins
Tetracycline Resistance

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Identifiers

PMID: 1584079
DOI: 10.1111/j.1348-0421.1992.tb01651.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1584079-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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