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Article

Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts.

EMBO reports - 1 May 2005

Mastroyiannopoulos Nikolaos P, Feldman Mariana L, Uney James B, Mahadevan Mani S, Phylactou Leonidas A

Abstract excerpt

The woodchuck post-transcriptional regulatory element (WPRE) can naturally accumulate hepatitis transcripts in the cytoplasm, and has been recently exploited as an enhancer of transgene expression. The retention of mutant myotonic dystrophy protein kinase (DMPK) transcripts in the nucleus of myotonic dystrophy (DM) cells has an important pathogenic role in the disease, resulting in pleiotropic effects including...

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Share to 3' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Regulator

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Source

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Identifiers

PMID: 15832171
DOI: 10.1038/sj.embor.7400390
PMCID: PMC1299300

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts.PMID 15832171Read ↗

Enhanced Expression of Transgenes from Adeno-Associated Virus Vectors with the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element: Implications for Gene TherapySemantic proximity Read ↗

Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.Semantic proximity Read ↗

Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral VectorsSemantic proximity Read ↗

Tackling the pathogenesis of RNA nuclear retention in myotonic dystrophy.Semantic proximity Read ↗

Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectorsSemantic proximity Read ↗

Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS.Semantic proximity Read ↗

Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts.Semantic proximity Read ↗

Trinucleotide-repeat expanded and normal DMPK transcripts contain unusually long poly(A) tails despite differential nuclear residence.Semantic proximity Read ↗

Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.Semantic proximity Read ↗

Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genesSemantic proximity Read ↗

Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding proteinSemantic proximity Read ↗

Cytoplasmic and nuclear retained DMPK mRNAs are targets for RNA interference in myotonic dystrophy cells.Semantic proximity Read ↗

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