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Origin and evolution of papillomavirus (onco)genes and genomes

8 Apr 2019

Abstract excerpt

Papillomaviruses (PVs) are ancient viruses infecting vertebrates, from fishes to mammals. Although the genomes of PVs are small and show conserved synteny, PVs display large genotypic diversity and ample variation in the phenotypic presentation of the infection. Most PV genomes contain two small early genes E6 and E7. In a bunch of closely related human papillomaviruses (HPVs), the E6 and E7 proteins provide the...

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PMID: 30955499
DOI: 10.1098/rstb.2018.0303

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