Article
Genetic variations in the DNA replication origins of human papillomavirus family correlate with their oncogenic potential.
Biochimica et biophysica acta. General subjects - 1 Apr 2018
Yilmaz Gulden, Biswas-Fiss Esther E, Biswas Subhasis B
Abstract excerpt
Human papillomaviruses (HPVs) encompass a large family of viruses that range from benign to highly carcinogenic. The crucial differences between benign and carcinogenic types of HPV remain unknown, except that the two HPV types differ in the frequency of DNA replication. We have systematically analyzed the mechanism of HPV DNA replication initiation in low-risk and high-risk HPVs. Our results demonstrate that...
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