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Article

Dual effect of tamoxifen on arterial KCa channels does not depend on the presence of the beta1 subunit.

The Journal of biological chemistry - 10 Jun 2005

Pérez Guillermo J

Abstract excerpt

Tamoxifen has been reported to directly activate large conductance calcium-activated potassium (KCa) channels through the KCa beta1 subunit, suggesting a cardio-protective role of this compound. The present study using knock-out (KO) mice for the KCa channel beta1 subunit was aimed at understanding the molecular mechanisms of the effects of tamoxifen on arterial smooth muscle KCa channels. Single channel studies...

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Identifiers

PMID: 15826942
DOI: 10.1074/jbc.M413953200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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