Mechanism of verapamil action on wild-type and slow-channel mutant human muscle acetylcholine receptor.

doi:10.1111/j.1471-4159.2010.06842.x

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Article

Mechanism of verapamil action on wild-type and slow-channel mutant human muscle acetylcholine receptor.

Journal of neurochemistry - 1 Aug 2010

Moriconi Claudia, Di Castro Maria Amalia, Fucile Sergio, Eusebi Fabrizio, Grassi Francesca

Abstract excerpt

Verapamil, a Ca(2+) channel blocker widely used in clinical practice, also affects the properties of frog and mouse muscle acetylcholine receptor (AChR). Here, we examine the mechanism of action of verapamil on human wild-type and slow-channel mutant muscle AChRs harboring in any subunit a valine-to-alanine mutation of 13' residue of the pore-lining M2 transmembrane segment. Verapamil, after a pre-treatment of...

Topics

Alanine
Amino Acid Substitution
Calcium Channel Blockers
Cells, Cultured
Humans
Ion Channel Gating
Mutation
Neuromuscular Junction
Point Mutation
Reaction Time
Receptors, Cholinergic
Synaptic Membranes
Valine
Verapamil

Source

Open in PubMed

Identifiers

PMID: 20533996
DOI: 10.1111/j.1471-4159.2010.06842.x

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