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Article

Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bond.

Protein engineering, design & selection : PEDS - 1 Mar 2005

Way Jeffrey C, Lauder Scott, Brunkhorst Beatrice, Kong Su-Ming, Qi An, Webster Gordon, Campbell Islay, McKenzie Sue, Lan Yan, Marelli Bo, Nguyen Lieu Anh, Degon Steven, Lo Kin-Ming, Gillies Stephen D

Abstract excerpt

Erythropoietin (Epo) is a cytokine that controls the production of red blood cells (RBCs). Epo acts continuously on RBC precursors to prevent apoptosis, so it is important to maintain high levels of Epo activity when treating anemic patients. We describe here modified human Epo [Epo(NDS)] with mutations His32Gly, Cys33Pro, Trp88Cys and Pro90Ala that result in the rearrangement of the disulfide bonding pattern...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15820978
DOI: 10.1093/protein/gzi021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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