Article
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jul 2012
Ekiz F, Ormeci N, Coban S, Karabulut H G, Aktas B, Tukun A, Tuncali T, Yüksel O, Alkış N
Abstract excerpt
Incidence of the esophagus adenocarcinoma has been dramatically increasing in Western countries since the last decade. Gastroesophageal reflux disease and Barrett's esophagus are risk factors for adenocarcinoma. Methylenetetrahydrofolate reductase (MTHFR) genes play a key role not only in folate metabolism but also in esophagus, stomach, pancreatic carcinoma, and acute leukemias. Studies have suggested that...
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