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Article

Transcarboxylase: one of nature's early nanomachines.

IUBMB life - 1 Oct 2004

Carey Paul R, Sönnichsen Frank D, Yee Vivien C

Abstract excerpt

The enzyme transcarboxylase (TC) catalyzes an unusual reaction; TC transfers a carboxylate group from methylmalonyl-CoA to pyruvate to form oxaloacetate and propionyl-CoA. Remarkably, to perform this task in Propionii bacteria Nature has created a large assembly made up of 30 polypeptides that totals 1.2 million daltons. In this nanomachine the catalytic machinery is repeated 6-12 times over using ordered arrays...

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Identifiers

PMID: 15814455
DOI: 10.1080/15216540400022417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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