Cumulative effects of spontaneous mutations for fitness in Caenorhabditis: role of genotype, environment and stress.

Abstract excerpt

It is often assumed that the mutation rate is an evolutionarily optimized property of a taxon. The relevant mutation rate is for mutations that affect fitness, U, but the strength of selection on the mutation rate depends on the average effect of a mutation. Determination of U is complicated by the possibility that mutational effects depend on the particular environmental context in which the organism exists. It...

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