Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenylbutyrate up-regulates the <i>adrenoleukodystrophy-related</i> gene as a nonclassical peroxisome proliferator

4 Apr 2005

Abstract excerpt

X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disease due to mutations in the ABCD1 (ALD) gene, encoding a peroxisomal ATP-binding cassette transporter (ALDP). Overexpression of adrenoleukodystrophy-related protein, an ALDP homologue encoded by the ABCD2 (adrenoleukodystrophy-related) gene, can compensate for ALDP deficiency. 4-Phenylbutyrate (PBA) has been shown to induce both ABCD2 expression and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Metabolism and Genetic Disorders
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15809314
DOI: 10.1083/jcb.200501036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenylbutyrate up-regulates the <i>adrenoleukodystrophy-related</i> gene as a nonclassical peroxisome proliferatorPMID 15809314Read ↗

Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy.Semantic proximity Read ↗

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophySemantic proximity Read ↗

Defective neuritogenesis in <i>Abcd1/2</i> deficient rat neurons due to intrinsic and astrocyte-dependent mechanismsSemantic proximity Read ↗

Fibrate induction of the adrenoleukodystrophy‐related gene (ABCD2)Semantic proximity Read ↗

Generating human AMN and cALD iPSC-derived astrocytes with potential for modeling X-linked adrenoleukodystrophy phenotypesSemantic proximity Read ↗

Role of family D ATP-binding cassette transporters (ABCD) in cancer.Semantic proximity Read ↗

Pharmacological induction of peroxisomes in peroxisome biogenesis disorders.Semantic proximity Read ↗

PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.Semantic proximity Read ↗

Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoformsSemantic proximity Read ↗

Effect of testosterone metabolites on ABC half-transporter relative gene expression in X-linked adrenoleukodystrophy.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells.Semantic proximity Read ↗

Up-regulation of nuclear PLCbeta1 in myogenic differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.