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Autoantibodies to citrullinated proteins: ACPA

1 Feb 2005

Abstract excerpt

Anti-perinuclear factor and anti-keratin antibodies have long been known to be specifically associated with rheumatoid arthritis (RA). They were first demonstrated to target various forms of (pro)filaggrin, a protein of stratified epithelia. Then, they were found to belong to a single family of autoantibodies targeting proteins that bear peptidic epitopes centered by a citrullyl residue: the anti-citrullinated...

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PMID: 15804701
DOI: 10.1080/08916930400022582

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