Article
Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway.
NMR in biomedicine - 1 Jan 2009
Morse David L, Carroll Danielle, Day Sam, Gray Heather, Sadarangani Pooja, Murthi Shiva, Job Constantin, Baggett Brenda, Raghunand Natarajan, Gillies Robert J
Abstract excerpt
Tumor choline metabolites have potential for use as diagnostic indicators of breast cancer phenotype and can be non-invasively monitored in vivo by MRS. Extract studies have determined that the principle diagnostic component of these peaks is phosphocholine (PCho), the biosynthetic precursor to the membrane phospholipid, phosphatidylcholine (PtdCho). The ability to resolve and quantify PCho in vivo would improve...
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