Article
SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children.
Human molecular genetics - 15 May 2005
Butcher Lee M, Meaburn Emma, Knight Jo, Sham Pak C, Schalkwyk Leonard C, Craig Ian W, Plomin Robert
Abstract excerpt
Mild mental impairment (MMI) represents the low extreme of the quantitative trait of general intelligence and is highly heritable. Quantitative trait loci (QTLs) conferring susceptibility to MMI, as for most complex traits, are likely to be of small effect size. Using a novel approach we call SNP-MaP (SNP Microarrays and Pooling), we have identified four loci associated with MMI. These four loci have been...
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