Article
CYP17 and tumor necrosis factor-alpha gene polymorphisms are associated with risk of oral cancer in Chinese patients in Taiwan.
Acta oto-laryngologica - 1 Jan 2005
Chen Wei-Cheng, Tsai Ming-Hsui, Wan Lei, Chen Wen-Chi, Tsai Chang-Hai, Tsai Fuu-Jen
Abstract excerpt
CONCLUSION: Patients who carry the T/T homozygote of CYP17 C/T gene polymorphism may have a higher risk of developing oral cancer. OBJECTIVE: Cancer of the oral cavity is the most commonly seen malignancy in Taiwan, and its rising incidence poses a formidable challenge to oncologists. The CYP17 gene encodes P450c17alpha, an enzyme involved in the metabolism of steroid hormones. Tumor necrosis factor-alpha...
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