Article
TNFalpha promoter polymorphism is a risk factor for susceptibility in hepatocellular carcinoma in Korean population.
Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2009
Jung Kang Wook, Ha Eunyoung, Yu Gyeong Im, Kim Sung Jin, Chung Woo Jin, Jang Byoung Kuk, Lee Jung Jeung, Shin Dong Hoon, Hwang Jae Seok
Abstract excerpt
BACKGROUND: The underlying genetic factors for the development and progression of hepatocellular carcinoma (HCC) are largely unknown. TNFalpha is a well characterized inflammatory mediator and is implicated in the development of HCC. We investigated TNFalpha polymorphisms for association with HCC. METHODS: The study population consisted of 227 HCC patients and 365 age and sex matched Korean controls. TNFalpha...
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