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Human Progesterone Receptor Displays Cell Cycle-Dependent Changes in Transcriptional Activity

29 Mar 2005

Abstract excerpt

The human progesterone receptor (PR) contains multiple Ser-Pro phosphorylation sites that are potential substrates for cyclin-dependent kinases, suggesting that PR activity might be regulated during the cell cycle. Using T47D breast cancer cells stably transfected with an mouse mammary tumor virus (MMTV) chloramphenicol acetyltransferase reporter (Cat0) synchronized in different phases of the cell cycle, we found...

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PMID: 15798179
DOI: 10.1128/mcb.25.8.2885-2898.2005

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