Article
Detection of p53 Gene Mutation (Single-Base Mismatch) Using a Fluorescent Silver Nanoclusters.
Journal of fluorescence - 1 Jul 2017
Hosseini Morteza, Mohammadi Shiva, Borghei Yasaman-Sadat, Ganjali Mohammad Reza
Abstract excerpt
P53 mutation was detected through the application of a biosensing approach based on the decrease in the fluorescence of oligonucleotide-templated silver nanoclusters (DNA-AgNCs). To this end specific DNA scaffolds of two various nucleotide fragments were used. One of the scaffolds was enriched with two cytosine sequence fragment (C12). This led to DNA-AgNCs with a fluorescence intensity through chemical...
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