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Article

Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.

Analytical chemistry - 1 Mar 2005

Kamchonwongpaisan Sumalee, Vanichtanankul Jarunee, Tarnchompoo Bongkoch, Yuvaniyama Jirundon, Taweechai Supannee, Yuthavong Yongyuth

Abstract excerpt

A simple method for screening combinatorial and other libraries of inhibitors of malarial (Plasmodium falciparum) dihydrofolate reductase (PfDHFR) has been developed, based on the affinities of the inhibitors with the enzyme. In the presence of limiting amounts of the enzyme, a number of inhibitors in the library were bound to extents reflecting the relative binding affinities. Following ultrafiltration and...

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Identifiers

PMID: 15732900
DOI: 10.1021/ac0487597

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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