Article
Immunoglobulin heavy chain sequence analysis in Waldenstrom's macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance.
Clinical lymphoma & myeloma - 1 Jul 2006
Rollett Rebecca A, Wilkinson Elizabeth J, Gonzalez David, Fenton James A L, Short Michael A, Evans Paul A S, Rawstron Andy C, Owen Roger G
Abstract excerpt
In this study, we used IGH sequence analysis to assess the maturational status of Waldenstrom's (WM) macroglobulinemia and its putative precursor immunoglobulin (Ig)-M monoclonal gammopathy of undetermined significance (MGUS). IGH sequence analysis was performed using standard methods in 23 cases (20 WM and 3 IgM MGUS as defined by consensus panel criteria). Waldenstrom's macroglobulinemia cases were...
Topics
- Aged
- Female
- Gene Rearrangement
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Male
- Middle Aged
- Mutation
- Paraproteinemias
- Sequence Analysis, DNA
- Waldenstrom Macroglobulinemia