Article
[Molecular and cellular changes following exposure to tobacco smoke causing laryngeal cancer. An outline of the problem].
Przeglad lekarski - 1 Jan 2004
Szyfter Krzysztof
Abstract excerpt
The incidence of laryngeal cancer is strongly connected with exposure to tobacco smoke containing at least 40 genotoxic carcinogens. DNA lesions induced by tobacco smoke carcinogens can be turned into stable mutations. Oncogenes and tumor suppressor genes are first of all responsible for initiation of carcinogenesis. The same time cells provide such self-protection processes as: carcinogen detoxication, DNA...
Topics
- Carcinogens
- DNA Damage
- DNA Repair
- Genes, Tumor Suppressor
- Humans
- Laryngeal Neoplasms
- Mutation
- Smoking
