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Gene Expression Profile Studies of Human Keratoconus Cornea for NEIBank: A Novel Cornea-Expressed Gene and the Absence of Transcripts for Aquaporin 5

24 Mar 2005

Abstract excerpt

PURPOSE: To increase the database of genes expressed in human cornea and to gain insights into the molecular basis of keratoconus (KC). METHODS: A cDNA library was constructed from KC corneas harvested at keratoplasty and used for expressed sequence tag (EST) analysis. Data were analyzed using grouping and identification of sequence tags (GRIST). Expression of selected clones was examined by RT-PCR. RESULTS: A...

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PMID: 15790884
DOI: 10.1167/iovs.04-1148

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