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Article

Post-translational processing of beta-secretase in Alzheimer's disease.

Proteomics - 1 Apr 2005

Sidera Christina, Parsons Richard, Austen Brian

Abstract excerpt

Beta-amyloid is released into the brains of Alzheimer's patients, where it aggregates and causes damage to neurons. It is cleaved proteolytically from a large transmembrane glycoprotein amyloid precursor protein by a membrane-bound protease, known as beta-secretase identified previously as the acid protease, Asp-2. We have shown previously that beta-secretase is up-regulated by increased intracellular...

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Identifiers

PMID: 15789346
DOI: 10.1002/pmic.200401185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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