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Article

RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549

11 Apr 2013

Abstract excerpt

PURPOSE: The E3 ubiquitin ligase RNF8 regulates the accumulation or removal of a number of proteins at DNA lesions, thereby playing a critically important role in DNA damage response. The present study investigated the possibility of using RNF8 as a new target in the radiation treatment of human non-small cell lung cancer. METHODS AND MATERIALS: We used RNA interference technology to silence the expression of...

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PMID: 23578064
DOI: 10.3109/09553002.2013.792964

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