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Article

DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A.

Journal of cell science - 15 Apr 2005

Ma Yinghong, Jacobs Stephanie B, Jackson-Grusby Laurie, Mastrangelo Mary-Ann, Torres-Betancourt José A, Jaenisch Rudolf, Rasmussen Theodore P

Abstract excerpt

In mammalian heterochromatin, cytosine bases of CpG dinucleotides are symmetrically modified by methylation. Patterns of CpG methylation are maintained by the action of Dnmt1, the mammalian maintenance cytosine methyltransferase enzyme. We genetically manipulated the levels of CpG methylation and found that extensive chromatin alterations occur in pericentric heterochromatin. Homozygous mutations in Dnmt1 cause...

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Identifiers

PMID: 15784683
DOI: 10.1242/jcs.02291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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