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Article

E93K charge reversal on actin perturbs steric regulation of thin filaments.

Journal of molecular biology - 15 Apr 2005

Cammarato Anthony, Craig Roger, Sparrow John C, Lehman William

Abstract excerpt

Contraction in striated muscles is regulated by Ca2+-dependent movement of tropomyosin-troponin on thin filaments. Interactions of charged amino acid residues between the surfaces of tropomyosin and actin are believed to play an integral role in this steric mechanism by influencing the position of tropomyosin on the filaments. To investigate this possibility further, thin filaments were isolated from...

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Identifiers

PMID: 15784249
DOI: 10.1016/j.jmb.2005.02.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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