Article
Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.
Journal of the neurological sciences - 15 Apr 2002
Fujimoto Takeshi, Nakamura Tatsufumi, Nishiura Yoshihiro, Ichinose Katsuhiro, Furuya Takafumi, Shirabe Susumu, Eguchi Katsumi
Abstract excerpt
We previously reported elevated levels of serum interleukin-12 (IL-12) in association with increased interferon-gamma (IFN-gamma) levels in patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The interaction between IL-12 and IL-12 receptor (IL-12R) plays an important role in differentiation of the T helper type 1 (Th1) phenotype. In this study,...
Topics
- Adult
- Aged
- CD4-Positive T-Lymphocytes
- CD40 Antigens
- Female
- Flow Cytometry
- Humans
- Interleukin-12
- Leukocytes, Mononuclear
- Male
- Middle Aged
- Paraparesis, Tropical Spastic
- Phenotype