Article
Type VII collagen is required for Ras-driven human epidermal tumorigenesis.
Science (New York, N.Y.) - 18 Mar 2005
Ortiz-Urda Susana, Garcia John, Green Cheryl L, Chen Lei, Lin Qun, Veitch Dallas P, Sakai Lynn Y, Lee Hyangkyu, Marinkovich M Peter, Khavari Paul A
Abstract excerpt
Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. To study the role of collagen VII in these cancers, we examined Ras-driven tumorigenesis in RDEB keratinocytes. Cells devoid of collagen VII did not form tumors in mice, whereas those retaining a specific collagen VII fragment (the amino-terminal noncollagenous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.