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Article

Collagen VII plays a dual role in wound healing

7 Jul 2013

Abstract excerpt

Although a host of intracellular signals is known to contribute to wound healing, the role of the cell microenvironment in tissue repair remains elusive. Here we employed 2 different mouse models of genetic skin fragility to assess the role of the basement membrane protein collagen VII (COL7A1) in wound healing. COL7A1 secures the attachment of the epidermis to the dermis, and its mutations cause a human skin...

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PMID: 23867500
DOI: 10.1172/jci68127

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