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Article

Development and Characterization of A Recombinant Truncated Type VII Collagen “Minigene”

1 Aug 2000

Abstract excerpt

Dystrophic epidermolysis bullosa (DEB) is an inherited mechano-bullous disorder of skin caused by mutations in the type VII collagen gene. The lack of therapy for DEB provides an impetus to develop gene therapy strategies. However, the full-length 9-kilobase type VII collagen cDNA exceeds the cloning capacity of current viral delivery vectors. In this study, we produced a recombinant type VII minicollagen...

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PMID: 10821839
DOI: 10.1074/jbc.m003440200

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