Article
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
Journal of the National Cancer Institute - 1 Jan 2016
Martins V L, Caley M P, Moore K, Szentpetery Z, Marsh S T, Murrell D F, Kim M H, Avari M, McGrath J A, Cerio R, Kivisaari A, Kähäri V M, Hodivala-Dilke K, Brennan C H, Chen M, Marshall J F, O'Toole E A
Abstract excerpt
BACKGROUND: Individuals with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop unexplained aggressive squamous cell carcinomas (SCC). Here we report that loss of type VII collagen (Col7) in SCC results in increased TGFβ signaling and angiogenesis in vitro and in vivo. METHODS: Stable knockdown (KD) of Col7 was...
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