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Article

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.

Journal of neurochemistry - 1 Apr 2005

Greggio Elisa, Bergantino Elisabetta, Carter Donald, Ahmad Rili, Costin Gertrude-Emilia, Hearing Vincent J, Clarimon Jordi, Singleton Andrew, Eerola Johanna, Hellström Olli, Tienari Pentti J, Miller David W, Beilina Alexandra, Bubacco Luigi, Cookson Mark R

Abstract excerpt

Tyrosinase is a key enzyme in the synthesis of melanin in skin and hair and has also been proposed to contribute to the formation of neuromelanin (NM). The presence of NM, which is biochemically similar to melanin in peripheral tissues, identifies groups of neurons susceptible in Parkinson's disease (PD). Whether tyrosinase is beneficial or detrimental to neurons is unclear; whilst the enzyme activity of...

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PMID: 15773923
DOI: 10.1111/j.1471-4159.2005.03019.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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