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Article

Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits.

Pigment cell & melanoma research - 1 Jul 2014

Jagirdar Kasturee, Smit Darren J, Ainger Stephen A, Lee Katie J, Brown Darren L, Chapman Brett, Zhen Zhao Zhen, Montgomery Grant W, Martin Nicholas G, Stow Jennifer L, Duffy David L, Sturm Richard A

Abstract excerpt

We have compared the melanogenic activities of cultured melanocytes carrying two common TYR alleles as homozygous 192S-402R wild-type, heterozygous and homozygous variant. This includes assays of TYR protein, DOPAoxidase activity, glycosylation and temperature sensitivity of protein and DOPAoxidase levels. Homozygous wild-type strains on average had higher levels of TYR protein and enzyme activity than other...

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Identifiers

PMID: 24739399
DOI: 10.1111/pcmr.12253
PMCID: PMC4119297

Genes

TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits.PMID 24739399Read ↗

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