A silent carbapenemase gene in strains of Bacteroides fragilis can be expressed after a one-step mutation.

doi:10.1016/0378-1097(92)90557-5

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Article

A silent carbapenemase gene in strains of Bacteroides fragilis can be expressed after a one-step mutation.

FEMS microbiology letters - 1 Feb 1992

Podglajen I, Breuil J, Bordon F, Gutmann L, Collatz E

Abstract excerpt

High-level carbapenem-resistant (CpmR) mutants, with MICs for imipenem and carbapenem of greater than 128 micrograms/ml, were selected in vitro from four carbapenem-susceptible (CpmS) clinical isolates of Bacteroides fragilis. The CpmS strains produced very low levels of beta-lactamase activity,...

Topics

Bacterial Outer Membrane Proteins
Bacteroides fragilis
Carbapenems
Genes, Bacterial
Mutagenesis
Mutation
Nucleic Acid Hybridization
Penicillin Resistance
beta-Lactamases

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