Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A silent carbapenemase gene in strains of Bacteroides fragilis can be expressed after a one-step mutation.

FEMS microbiology letters - 1 Feb 1992

Podglajen I, Breuil J, Bordon F, Gutmann L, Collatz E

Abstract excerpt

High-level carbapenem-resistant (CpmR) mutants, with MICs for imipenem and carbapenem of greater than 128 micrograms/ml, were selected in vitro from four carbapenem-susceptible (CpmS) clinical isolates of Bacteroides fragilis. The CpmS strains produced very low levels of beta-lactamase activity, which was increased approx. 50- to 100-fold in the CpmR mutants. Isoelectric focussing and enzyme kinetic analysis (Km...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to beta-Lactamases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carbapenems

Share to Genes, Bacterial

Share to Mutagenesis

Share to Mutation

Share to Nucleic Acid Hybridization

Share to Penicillin Resistance

Source

Identifiers

PMID: 1577251
DOI: 10.1016/0378-1097(92)90557-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A silent carbapenemase gene in strains of Bacteroides fragilis can be expressed after a one-step mutation.PMID 1577251Read ↗

Expression of the carbapenemase gene (cfiA) in Bacteroides fragilisSemantic proximity Read ↗

Insertion of a novel DNA sequence, IS <i>1186</i>, upstream of the silent carbapenemase gene <i>cfiA</i>, promotes expression of carbapenem resistance in clinical isolates of <i>Bacteroides fragilis</i>Semantic proximity Read ↗

Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolatesSemantic proximity Read ↗

Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases.Semantic proximity Read ↗

Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing.Semantic proximity Read ↗

Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwideSemantic proximity Read ↗

Low-level resistance to rifampin in Streptococcus pneumoniae.Semantic proximity Read ↗

Genetic determinants for cfxA expression in Bacteroides strains isolated from human infectionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.